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KMID : 0358319960370101087
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Korean Journal of Urology
1996 Volume.37 No. 10 p.1087 ~ p.1092
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Study of the Allelic Frequency on Polymorphic Loci in the Short Arm of Chromosome 3 in Normal Koreans
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Abstract
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The results of allelic frequency of polymorphic loci in the short arm of chromosome 3 in normal Koreans are shown using a polymerase chain reaction (PCR) based restriction fragment length polymorphism analysis on blood samples of 20 males and 20
females
without any tumor or hereditary disease.
The allelic frequency of two loci, D3S2 (MspI) and D3F15S2 (HindⅢ0 was quite different between renal cell carcinoma in Koreans and Cocassians, but THRB (MspI) iocus was similar. This suggests the importance of determining specific loci to
Koreans.
The
study of tumor suppressor gene on these genetic loci due to D3S2 (MspI) and THRB (EcoRI) loci showed high constitutional heterozygosity, contrast to D3F15S2 (HindⅢ), THRB (BamH) and THRB (MspI) loci where low constitutional heterozygosity were
seen.
Therefore, the study of tumor suppressor gene should be directed to investigate. This study showed the allelic distribution of Koreans differing from Concaccians and the genetic locus with the high frequency of heterozygosity among the
polymorphic
loci
comparable to Koreans were due to the difference of heterozygosity frequency according to genetic loci.
Therefore, the author thinks that the need for the detection of specific genetic loci for Koreans to study the correlation among many cases for clarrifying the tumorigenesis and active research should be initiated to find other genetic locus
related to
multi-step tumorigenesis.
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KEYWORD
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